That enormous numbers highlight the need to develop a novel, effective therapeutic intervention and fully unravel the molecular mechanisms leading to disease development. The estimated cost of osteoporosis management is estimated an average of $17–$20 billion per year. As reported by Food and Drug Administration (FDA) only in United States of America currently near 10 million of patients suffer from osteoporosis, contributing to economic burden on the health care system. According to the definition of osteoporosis introduced by World Health Organization (WHO), osteoporotic patient exhibits reduction in bone mineral density (BMD) of 2.5 standard deviations or more, below that of the mean peak BMD of young adults when measured by dual-energy X-ray absorptiometry (DEXA). Decreased biomechanical properties and impaired young modulus of osteoporotic bones contribute to great risk of fractures. ![]() All of that predispose to the development of osteoporosis, disease defined by massive bone loss and significant changes in bone microarchitecture. Due to progressive aging of population, the bone tissue is affected by deterioration of its composition, structure and function. The role of these research areas is especially profound in studying of bone diseases which nowadays requires interdisciplinary approach combining basic, clinical and translational studies. This new branch of medical sciences targets not only regeneration of damage tissues, but also attempts to visualize regeneration process in vivo. In recent years, regenerative medicine as well as theranostics are rapidly developing fields of medicine. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Oh, and if you've yet to play Dead Cells, you can pick it up on sale for $4.99 (50% off) until September 28th, which is a pretty good deal considering Dead Cells is one of the best platformers on the platform.Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Of course, if you'd like to see what's new, simply update the game, and if you're itching to check out the new Fatal Falls' content, you can purchase the Fatal Falls DLC through a single IAP. ![]() NEW FREE UPDATE - Custom Mode update, new biome, new monsters, new weapons.įATAL FALLS DLC - New biomes, new monsters, new boss, new weapons and items So even old players who don't plan on purchasing today's DLC are in for a treat. ![]() Not only is there new content available with the release of the Fatal Falls DLC, but thanks to today's update, there are also some free goodies, such as a new biome, eight new weapons, and nine new monsters. Above you can watch the trailer for the Fatal Falls mobile launch, which offers a glimpse of the new biomes available, along with some of the new enemies and weapons.
0 Comments
Leave a Reply. |